Shepherdstown is situated in eastern West Virginia, convenient to Washington, D.C., and to many nearby cities in West Virginia, Virginia, Maryland, and Pennsylvania. If you’re driving, here are some of the most frequently used routes to the campus.
From the North or South
- Follow Interstate 81 to Martinsburg, West Virginia, and take Exit 16 East (Route 9 East) into Martinsburg.
- Turn left onto Route 45 East, and follow Route 45 into Shepherdstown.
- Proceed through the four-way stop sign.
- When you get to Shepherdstown, proceed two more blocks on German Street then turn left on to King Street, the main street of the Shepherd campus.
- Proceed another block to the intersection of King Street and High Street. Proceed straight. The Office of Admissions is on King Street, on the first floor of Ikenberry Hall, the third building on the right.
From the West
- Follow Interstate 70 East to Hagerstown, Maryland.
- In Hagerstown follow Interstate 81 South to Martinsburg, West Virginia, and take Exit 16 East (Route 9 East) into Martinsburg.
- Turn left onto Route 45 East, and follow Route 45 into Shepherdstown.
- Proceed through the four-way stop sign.
- When you get to Shepherdstown, proceed two more blocks on German Street then turn left on to King Street, the main street of the Shepherd campus.
- Proceed another block to the intersection of King Street and High Street. Proceed straight. The Office of Admissions is on King Street, on the first floor of Ikenberry Hall, the third building on the right.
From the East
- Follow Interstate 70 or 270 West from Baltimore, Maryland or Washington, D.C., to Frederick, Maryland, and take Exit 49 (alternate Route 40 West).
- Follow Alternate Route 40 through Middletown to Boonsboro, Maryland.
- In Boonsboro turn left onto Route 34, and follow Route 34 through Sharpsburg across the Potomac River into Shepherdstown.
- Turn left at the four-way stop sign onto Route 45 (German Street).
- When you get to Shepherdstown, proceed two more blocks on German Street to King Street, the main street of the Shepherd campus.
- Proceed another block to the intersection of King Street and High Street. Proceed straight. The Office of Admissions is on King Street, on the first floor of Ikenberry Hall, the third building on the right.
Estimated Driving Times to Shepherd University
| Location | Distance | Time |
| Annapolis, MD | 100 miles | 1.75 hours |
| Baltimore, MD | 70 miles | 1.25 hours |
| Charleston, WV | 300 miles | 5 hours |
| Cumberland, MD | 85 miles | 1.5 hours |
| Gettysburg, PA | 60 miles | 1.25 hours |
| Morgantown, WV | 175 miles | 2.75 hours |
| Philadelphia, PA | 185 miles | 3 hours |
| Pittsburgh, PA | 225 miles | 3.5 hours |
| Richmond, VA | 180 miles | 3 hours |
| Washington, DC | 65 miles | 1 hour |
| Wheeling, WV | 240 miles | 4 hours |
| Winchester, VA | 35 miles | 45 minutes |